Wastewater sampling could be key to early warning of new disease outbreaks | Medical research

Wastewater sampling could predict new disease outbreaks and the emergence of new variants of pathogens weeks or months before they become widespread, new research shows. Pathogen monitoring in sewer systems, including on airplanes, can reveal which viruses and bacteria are present and cause outbreaks, two studies indicate. Wastewater monitoring is not invasive – it does … Read more

First Thing: Trump says administration ‘just getting started’ in address to Congress | US news

Good morning. Donald Trump used his lengthy address to Congress on Tuesday to declare that his administration was “just getting started”, hailing his purging of the federal workforce, upending of foreign policy and intensification of a risky trade war as the beginning of the “most thrilling days in the history” of the US. At one … Read more

IRS workforce ‘could halve’ after Trump hails cuts to federal staffing in marathon Congress speech – US politics live | US news

Key events Show key events only Please turn on JavaScript to use this feature Opening summary Welcome to the Guardian’s live coverage of US politics and the Donald Trump administration. I’m Tom Ambrose. We start with news that the Internal Revenue Service (IRS) is considering reducing its workforce by as much as 50%, according to … Read more

Exile is ‘a little bit less than death’ for lawyer forced to flee Guatemala | Guatemala

A Guatemalan anti-corruption prosecutor forced into exile after being pursued by the country’s conservative elite has said that leaving the country was the only way to save her life but was only “a little bit less than death”. Virginia Laparra, 45, spent two years in prison for allegedly abusing her position after she reported her … Read more

Green light for £1.2bn ‘bulk mail’ claim against Royal Mail owner to go to trial | Royal Mail

A £1.2bn class action claim accusing the owner of Royal Mail of abusing its “dominant position” in the market for sending bulk mail has been given the green light to proceed to trial by UK competition authorities. Bulk Mail Claim Ltd, a recently formed company representing an estimated 290,000 customers who claim they were overcharged … Read more

Minister says welfare budget ‘unsustainable’ amid reports Reeves has earmarked billions in cuts – UK politics live | Politics

Good morning. Three weeks today Rachel Reeves, the chancellor, will present her spring statement. Originally this was not meant to involve budget-scale changes for plans to tax or spending (Reeves says she is only going to have one proper budget a year, in the autumn, to ensure stability), but changes to the country’s economic situation … Read more

Arab leaders endorse Gaza rebuild scheme as alternative to Trump’s plan to ‘take over’ region – Middle East crisis live | World news

Opening summary Arab leaders have endorsed a plan to rebuild the Gaza Strip under the future administration of the Palestinian Authority (PA), presenting an alternative to US president Donald Trump’s widely condemned proposal to take over the territory and displace its people. The prospect of the PA governing Gaza remains far from certain, however, reports … Read more